Alzheimer's Disease and Related Conditions (A Ciba by G. E. W. Wolstenholme, Maeve O'Connor

By G. E. W. Wolstenholme, Maeve O'Connor

Chapter 1 Chairman's beginning comments (pages 1–3): Professor M. Roth
Chapter 2 Alois Alzheimer and his disorder (pages 5–9): W. H. McMenemey
Chapter three the concept that of Alzheimer's affliction and its medical Implications (pages 11–36): Patrick Sourander and Hakon Sjogren
Chapter four The Limbic components in Alzheimer's disorder and in different stipulations linked to Dementia (pages 37–50): J. A. N. Corsellis
Chapter five Circumscribed Cerebral Atrophy in Alzheimer's illness: A Pathological examine (pages 51–73): I. Tariska
Chapter 6 Muscular Twitchings in Alzheimer's disorder (pages 75–93): H. Jacob
Chapter 7 Cerebral Amyloid Angiopathy and Alzheimer's sickness (pages 95–104): Ludo van Bogaert
Chapter eight abnormal Alzheimer's illness with Congophilic Angiopathy featuring with Dementia of Acute Onset (pages 105–135): D. Hollander and S. J. Strich
Chapter nine The Genetics of Alzheimer's disorder (pages 137–143): R. T. C. Pratt
Chapter 10 The Ultrastructure of the Neurofibrillary Tangle and the Senile Plaque (pages 145–168): Robert D. Terry and Henryk Wisniewski
Chapter eleven The Pathology of the Synapse in Alzheimer's illness (pages 169–183): Nicholas ok. Gonatas and Pierluigi Gambetti
Chapter 12 Neurofibrillary alterations in stipulations with regards to Alzheimer's disorder (pages 185–207): Asao Hirano
Chapter thirteen selection of Neurofilament and Microtubule Density in Nerve Fibres (What elements keep an eye on Axon Calibre?) (pages 209–222): R. L. Friede
Chapter 14 An Experimental method of the Morphogenesis of Neurofibrillary Degeneration and the Argyrophilic Plaque (pages 223–248): Henryk Wisniewski and Robert D. Terry
Chapter 15 Biochemistry of Neurofilaments and Neurotubules (pages 249–266): Michael L. Shelanski and Edwin W. Taylor
Chapter sixteen Metabolism of Microtubular Protein in Mouse mind (pages 267–299): Samuel H. Barondes and Howard Feit
Chapter 17 Chairman's remaining comments (pages 301–305): Professor M. Roth

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Progress in Brain Research, vol. 1 Amsterdam: Elsevier. DIEZEL, P. , and VOGEL, M. (1965). Biblthcapsychiat. , 127, 40-64. DIVRY,P. (1934). /. belg. Neurol. , 34, 197-201. DIVRY,P. (1935). /. belg. Neurol. , 35, 565-590. DIVRY,P. (1939). ]. belg. Neural. , 39, 444-461. L. J,, HAMBERGER, A,, and SJOSTRAND, J. (1967). ]. Neuropath. exp. , 26, EMBREE, 427-43 6. ESSEN-MOLLER, E. (1946). Acta psychiat. itenrol. , 21, 233-244. FRIEDE, R. L. (1962). , 12, 213-222. FRIEDE, R. L. (1965). ]. Neuropath. exp.

Von Brauiimiihl impregnation x 50. When Broca delineated the “great limbic lobe” in 1878, he claimed that it represented the “brutish” part of the forebrain, whereas the rest of the cerebral mantle, which he called the extra-limbic mass, was concerned mainly with intelligence. This concept of a limbic lobe, or even a limbic system, has always aroused both suspicion and enthusiasm. -c 44 J. A . N. C O R S E L L I S that the idea then held for many writers, while nine years later he was talking about the genius ofBroca and ofreturning once again to the concept of the limbic lobe.

Extreme and rapid decrease in body wcight, apparently unrelated to inadequate feeding and to cancer, was a common finding in the terminal stage of Alzheimer’s disease in our material. In our material the limbic structures which arc regarded as related to hypothalamic and endocrine functions were severely affected. A careful search for signs and symptoms of possible endocrine dysfunction is therefore necessary. Almost 3 0 years ago McMenemey (1940)stressed the need for a more complete histological examination of other organs of the body in Alzheimer’s disease.

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